Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

M. Solimena; A.M. Schulte; L. Marselli; F. Ehehalt; D. Richter; M. Kleeberg; H. Mziaut; K.P. Knoch; J. Parnis; M. Bugliani; A. Siddiq; A. Jörns; F. Burdet; R. Liechti; M. Suleiman; D. Margerie; F. Syed; M. Distler; R. Grützmann; E. Petretto; A. Moreno-Moral; C. Wegbrod; A. Sönmez; K. Pfriem; A. Friedrich; J. Meinel; C.B. Wollheim; G.B. Baretton; R. Scharfmann; E. Nogoceke; E. Bonifacio; D. Sturm; B. Meyer-Puttlitz; U. Boggi; H.D. Saeger; F. Filipponi; M. Lesche; P. Meda; A. Dahl; L. Wigger; I. Xenarios; M. Falchi; B. Thorens; J. Weitz; K. Bokvist; S. Lenzen; G.A. Rutter; P. Froguel; M. von Bülow; M. Ibberson; P. Marchetti

Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

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Anglais

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doi: 10.1007/s00125-017-4500-3
issn: 0012-186X

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00125-017-4500-3

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info:eu-repo/semantics/altIdentifier/pmid/29185012

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info:eu-repo/semantics/altIdentifier/eissn/1432-0428

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4B55984D6D1A8

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Aged; Aged, 80 and over; Biological Specimen Banks; Computational Biology; Diabetes Mellitus, Type 2/metabolism; Female; Humans; Male; Pancreatectomy; Systems Biology/methods; Tissue Donors; Transcriptome/genetics; Beta cell; Biobank; Diabetes; Gene expression; Insulin secretion; Islet; Laser capture microdissection; Organ donor; Systems biology

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Isles Islets Type 1 diabetes Brittle diabetes IDDM (Disease) Ketosis prone diabetes Diabetes mellitus Insulin-dependent diabetes

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M. Solimena et al., « Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes. », Serveur académique Lausannois, ID : 10.1007/s00125-017-4500-3

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Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in Diabetes (IMIDIA) consortium ( www.imidia.org ) established a comprehensive, unique multicentre biobank of human islets and pancreas tissues from organ donors and metabolically phenotyped pancreatectomised patients (PPP). Affymetrix microarrays were used to assess the islet transcriptome of islets isolated either by enzymatic digestion from 103 organ donors (OD), including 84 non-diabetic and 19 type 2 diabetic individuals, or by laser capture microdissection (LCM) from surgical specimens of 103 PPP, including 32 non-diabetic, 36 with type 2 diabetes, 15 with impaired glucose tolerance (IGT) and 20 with recent-onset diabetes (

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Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.

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