Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.

Clear cell carcinoma Renal cell adenocarcinoma Grawitz's tumor Adenocarcinoma of kidney Grawitz tumor Hypernephroid carcinoma Renal adenocarcinoma Hypernephroma Units of inheritance Units of heredity Survival skills Survival after airplane accidents, shipwrecks, etc Ribose nucleic acid Ribonucleic acid Primary metabolism Anabolism Metabolism, Primary Catabolism Tubules, Kidney Renal tubules Nephron Fusion, Gene Expressive behavior Deoxyribonucleic acid TNA (Nucleic acid) Desoxyribonucleic acid Thymonucleic acid Knowledge, Classification of illness

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F. Chen et al., « Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma. », Serveur académique Lausannois, ID : 10.1016/j.celrep.2016.02.024

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On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary RCC. Widespread molecular changes associated with TFE3 gene fusion or chromatin modifier genes were present within a specific subtype and spanned multiple subtypes. Differences in patient survival and in alteration of specific pathways (including hypoxia, metabolism, MAP kinase, NRF2-ARE, Hippo, immune checkpoint, and PI3K/AKT/mTOR) could further distinguish the subtypes. Immune checkpoint markers and molecular signatures of T cell infiltrates were both highest in the subtype associated with aggressive clear cell RCC. Differences between the genomic subtypes suggest that therapeutic strategies could be tailored to each RCC disease subset.

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Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.

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