Simultaneous Quantification of Bisphenol A, Its Glucuronide Metabolite, and Commercial Alternatives by LC-MS/MS for In Vitro Skin Absorption Evaluation.
Fiche du document
21 septembre 2020
- doi: 10.1021/acs.chemrestox.0c00148
- issn: 0893-228X
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.chemrestox.0c00148
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/32840112
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1520-5010
Ce document est lié à :
info:eu-repo/grantAgreement/FOUNDATION_SCAHT/////
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_FA7C8675D92F1
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Cutaneous absorption Percutaneous absorptionCiter ce document
E. Reale et al., « Simultaneous Quantification of Bisphenol A, Its Glucuronide Metabolite, and Commercial Alternatives by LC-MS/MS for In Vitro Skin Absorption Evaluation. », Serveur académique Lausannois, ID : 10.1021/acs.chemrestox.0c00148
Métriques
Partage / Export
Résumé
Bisphenol A (BPA) is the most used color developer in thermal paper products such as cashiers' receipts, followed by Bisphenol S (BPS), Wincon 8 (D-8), and Pergafast 201 (PF201). These chemicals can migrate from the paper onto the skin and possibly be absorbed and metabolized. Until now, D-8 and PF201 have not been analyzed in biological matrices, nor has a method been developed to simultaneously quantify them, even though they are often found as mixtures. Our aim was to develop and validate a method to quantify BPA, its glucuronide metabolite (BPA-G), BPS, D-8, and PF201 in in vitro skin absorption samples. After solid-phase extraction and reversed-phase chromatography, we quantified the substances in saline that had been in contact with human dermis for 24 h using a triple-quadrupole mass detector equipped with an electrospray ionization source. We assessed the method in three in vitro skin absorption assays using ex vivo human skin from one skin donor per test substance. The quantification ranges of our method were 0.2-200 μg/L for BPA and 0.2-20 μg/L for BPA-G, BPS, D-8, and PF201. Accuracies were within ±8% of nominal concentrations. Intra-day and total precisions (%RSD) were