Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies.

Hormones Endogenous; T.J. Key; P.N. Appleby; G.K. Reeves; A.W. Roddam; K.J. Helzlsouer; A.J. Alberg; D.E. Rollison; J.F. Dorgan; L.A. Brinton; K. Overvad; R. Kaaks; A. Trichopoulou; F. Clavel-Chapelon; S. Panico; E.J. Duell; P.H. Peeters; S. Rinaldi; I.S. Fentiman; M. Dowsett; J. Manjer; P. Lenner; G. Hallmans; L. Baglietto; D.R. English; G.G. Giles; J.L. Hopper; G. Severi; H.A. Morris; S.E. Hankinson; S.S. Tworoger; K. Koenig; A. Zeleniuch-Jacquotte; A.A. Arslan; P. Toniolo; R.E. Shore; V. Krogh; A. Micheli; F. Berrino; E. Barrett-Connor; G.A. Laughlin; M. Kabuto; S. Akiba; R.G. Stevens; K. Neriishi; C.E. Land; J.A. Cauley; L.Y. Lui; S.R. Cummings; M.J. Gunter; T.E. Rohan; H.D. Strickler

Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies.

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2011

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Anglais

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doi: 10.1038/bjc.2011.254
issn: 0007-0920

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/bjc.2011.254

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/21772329

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1532-1827

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_DC30782A8EF51

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Adult; Aged; Aged, 80 and over; Breast Neoplasms/blood; Breast Neoplasms/etiology; Carcinoma/blood; Carcinoma/etiology; Cross-Sectional Studies; Female; Gonadal Steroid Hormones/blood; Humans; Middle Aged; Postmenopause/blood; Pregnancy; Retrospective Studies; Risk Factors

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Womyn Wimmin Woman Womon Human females Breasts Women's work

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Hormones Endogenous et al., « Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. », Serveur académique Lausannois, ID : 10.1038/bjc.2011.254

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BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer. CONCLUSION: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk.

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Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies.

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