Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q.
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2011
- doi: 10.1038/leu.2010.231
- issn: 0887-6924
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Abnormities and deformities Deformities Plants--Deformities Deformities in plants Abnormalities in plants Abnormalities (Plants) Botany--Teratology Abnormalities Malformations in animals Abnormalities (Animals) Animals--Malformations Animal abnormalities Animal malformations Zoology--Teratology Abnormalities in animals Deformities in animals Animals--Deformities Animal deformities Abnormalities Defects, Birth Malformations, Congenital Congenital anomalies Developmental abnormalities Congenital abnormalities Anomalies, Congenital Human abnormalities Deformities Birth defects AbnormalitiesCiter ce document
M. Mallo et al., « Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q. », Serveur académique Lausannois, ID : 10.1038/leu.2010.231
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This cooperative study assessed prognostic factors for overall survival (OS) and risk of transformation to acute myeloid leukemia (AML) in 541 patients with de novo myelodysplastic syndrome (MDS) and deletion 5q. Additional chromosomal abnormalities were strongly related to different patients' characteristics. In multivariate analysis, the most important predictors of both OS and AML transformation risk were number of chromosomal abnormalities (P