Landscape of transcription in human cells.

S. Djebali; C.A. Davis; A. Merkel; A. Dobin; T. Lassmann; A. Mortazavi; A. Tanzer; J. Lagarde; W. Lin; F. Schlesinger; C. Xue; G.K. Marinov; J. Khatun; B.A. Williams; C. Zaleski; J. Rozowsky; M. Röder; F. Kokocinski; R.F. Abdelhamid; T. Alioto; I. Antoshechkin; M.T. Baer; N.S. Bar; P. Batut; K. Bell; I. Bell; S. Chakrabortty; X. Chen; J. Chrast; J. Curado; T. Derrien; J. Drenkow; E. Dumais; J. Dumais; R. Duttagupta; E. Falconnet; M. Fastuca; K. Fejes-Toth; P. Ferreira; S. Foissac; M.J. Fullwood; H. Gao; D. Gonzalez; A. Gordon; H. Gunawardena; C. Howald; S. Jha; R. Johnson; P. Kapranov; B. King; C. Kingswood; O.J. Luo; E. Park; K. Persaud; J.B. Preall; P. Ribeca; B. Risk; D. Robyr; M. Sammeth; L. Schaffer; L.H. See; A. Shahab; J. Skancke; A.M. Suzuki; H. Takahashi; H. Tilgner; D. Trout; N. Walters; H. Wang; J. Wrobel; Y. Yu; X. Ruan; Y. Hayashizaki; J. Harrow; M. Gerstein; T. Hubbard; A. Reymond; S.E. Antonarakis; G. Hannon; M.C. Giddings; Y. Ruan; B. Wold; P. Carninci; R. Guigó; T.R. Gingeras

Landscape of transcription in human cells.

Fiche du document

Auteurs

Date

2012

Type de document

Articles

Périmètre

Publications

Langue

Anglais

Identifiants

doi: 10.1038/nature11233
issn: 0028-0836

Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/nature11233

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/22955620

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1476-4687

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_7207A3318E3D0

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Alleles; Cell Line; DNA/genetics; DNA, Intergenic/genetics; Encyclopedias as Topic; Enhancer Elements, Genetic; Exons/genetics; Gene Expression Profiling; Genes/genetics; Genome, Human/genetics; Genomics; Humans; Molecular Sequence Annotation; Polyadenylation/genetics; Protein Isoforms/genetics; RNA/biosynthesis; RNA/genetics; RNA Editing/genetics; RNA Splicing/genetics; Regulatory Sequences, Nucleic Acid/genetics; Repetitive Sequences, Nucleic Acid/genetics; Sequence Analysis, RNA; Transcription, Genetic/genetics; Transcriptome/genetics

Sujets proches En

Ribose nucleic acid Ribonucleic acid

Citer ce document

S. Djebali et al., « Landscape of transcription in human cells. », Serveur académique Lausannois, ID : 10.1038/nature11233

Partage / Export

Résumé 0

Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene.

{"uri":"10.1038\/nature11233","creators":[{"id":"djebali_s","lastname":"Djebali"},{"id":"davis_c_a","lastname":"Davis"},{"id":"merkel_a","lastname":"Merkel"},{"id":"dobin_a","lastname":"Dobin"},{"id":"lassmann_t","lastname":"Lassmann"},{"id":"mortazavi_a","lastname":"Mortazavi"},{"id":"tanzer_a","lastname":"Tanzer"},{"id":"lagarde_j","lastname":"Lagarde"},{"id":"lin_w","lastname":"Lin"},{"id":"schlesinger_f","lastname":"Schlesinger"},{"id":"xue_c","lastname":"Xue"},{"id":"marinov_g_k","lastname":"Marinov"},{"id":"khatun_j","lastname":"Khatun"},{"id":"williams_b_a","lastname":"Williams"},{"id":"zaleski_c","lastname":"Zaleski"},{"id":"rozowsky_j","lastname":"Rozowsky"},{"id":"roder_m","lastname":"R\u00f6der"},{"id":"kokocinski_f","lastname":"Kokocinski"},{"id":"abdelhamid_r_f","lastname":"Abdelhamid"},{"id":"alioto_t","lastname":"Alioto"},{"id":"antoshechkin_i","lastname":"Antoshechkin"},{"id":"baer_m_t","lastname":"Baer"},{"id":"bar_n_s","lastname":"Bar"},{"id":"batut_p","lastname":"Batut"},{"id":"bell_k","lastname":"Bell"},{"id":"bell_i","lastname":"Bell"},{"id":"chakrabortty_s","lastname":"Chakrabortty"},{"id":"chen_x","lastname":"Chen"},{"id":"chrast_j","lastname":"Chrast"},{"id":"curado_j","lastname":"Curado"},{"id":"derrien_t","lastname":"Derrien"},{"id":"drenkow_j","lastname":"Drenkow"},{"id":"dumais_e","lastname":"Dumais"},{"id":"dumais_j","lastname":"Dumais"},{"id":"duttagupta_r","lastname":"Duttagupta"},{"id":"falconnet_e","lastname":"Falconnet"},{"id":"fastuca_m","lastname":"Fastuca"},{"id":"fejes_toth_k","lastname":"Fejes-Toth"},{"id":"ferreira_p","lastname":"Ferreira"},{"id":"foissac_s","lastname":"Foissac"},{"id":"fullwood_m_j","lastname":"Fullwood"},{"id":"gao_h","lastname":"Gao"},{"id":"gonzalez_d","lastname":"Gonzalez"},{"id":"gordon_a","lastname":"Gordon"},{"id":"gunawardena_h","lastname":"Gunawardena"},{"id":"howald_c","lastname":"Howald"},{"id":"jha_s","lastname":"Jha"},{"id":"johnson_r","lastname":"Johnson"},{"id":"kapranov_p","lastname":"Kapranov"},{"id":"king_b","lastname":"King"},{"id":"kingswood_c","lastname":"Kingswood"},{"id":"luo_o_j","lastname":"Luo"},{"id":"park_e","lastname":"Park"},{"id":"persaud_k","lastname":"Persaud"},{"id":"preall_j_b","lastname":"Preall"},{"id":"ribeca_p","lastname":"Ribeca"},{"id":"risk_b","lastname":"Risk"},{"id":"robyr_d","lastname":"Robyr"},{"id":"sammeth_m","lastname":"Sammeth"},{"id":"schaffer_l","lastname":"Schaffer"},{"id":"see_l_h","lastname":"See"},{"id":"shahab_a","lastname":"Shahab"},{"id":"skancke_j","lastname":"Skancke"},{"id":"suzuki_a_m","lastname":"Suzuki"},{"id":"takahashi_h","lastname":"Takahashi"},{"id":"tilgner_h","lastname":"Tilgner"},{"id":"trout_d","lastname":"Trout"},{"id":"walters_n","lastname":"Walters"},{"id":"wang_h","lastname":"Wang"},{"id":"wrobel_j","lastname":"Wrobel"},{"id":"yu_y","lastname":"Yu"},{"id":"ruan_x","lastname":"Ruan"},{"id":"hayashizaki_y","lastname":"Hayashizaki"},{"id":"harrow_j","lastname":"Harrow"},{"id":"gerstein_m","lastname":"Gerstein"},{"id":"hubbard_t","lastname":"Hubbard"},{"id":"reymond_a","lastname":"Reymond"},{"id":"antonarakis_s_e","lastname":"Antonarakis"},{"id":"hannon_g","lastname":"Hannon"},{"id":"giddings_m_c","lastname":"Giddings"},{"id":"ruan_y","lastname":"Ruan"},{"id":"wold_b","lastname":"Wold"},{"id":"carninci_p","lastname":"Carninci"},{"id":"guigo_r","lastname":"Guig\u00f3"},{"id":"gingeras_t_r","lastname":"Gingeras"}]}

Landscape of transcription in human cells.

Fiche du document

Mots-clés 0

Sujets proches En

Citer ce document

Métriques

Partage / Export

Résumé 0

Par les mêmes auteurs

Sur les mêmes sujets

Exporter en