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2015
- doi: 10.1038/nature14177
- issn: 0028-0836
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info:eu-repo/semantics/altIdentifier/doi/10.1038/nature14177
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info:eu-repo/semantics/altIdentifier/pmid/25673413
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info:eu-repo/semantics/altIdentifier/eissn/1476-4687
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_F373E38AD7603
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Fatness Corpulence Overweight AdiposityCiter ce document
A.E. Locke et al., « Genetic studies of body mass index yield new insights for obesity biology », Serveur académique Lausannois, ID : 10.1038/nature14177
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Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.