Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
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2013
- doi: 10.1038/ng.2610
- issn: 1061-4036
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Cycle, Cardiac Cardiac cycle Heart rate Heart cycleCiter ce document
M. den Hoed et al., « Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. », Serveur académique Lausannois, ID : 10.1038/ng.2610
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Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate-increasing and heart rate-decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.