Vitamin D and cognitive function: A Mendelian randomisation study.

J. Maddock; A. Zhou; A. Cavadino; E. Kuźma; Y. Bao; M.C. Smart; K.U. Saum; B. Schöttker; J. Engmann; M. Kjærgaard; V. Karhunen; Y. Zhan; T. Lehtimäki; S.P. Rovio; L. Byberg; J. Lahti; P. Marques-Vidal; A. Sen; L. Perna; H. Schirmer; A. Singh-Manoux; J. Auvinen; N. Hutri-Kähönen; M. Kähönen; L. Kilander; K. Räikkönen; H. Melhus; E. Ingelsson; I. Guessous; K.E. Petrovic; H. Schmidt; R. Schmidt; P. Vollenweider; L. Lind; J.G. Eriksson; K. Michaëlsson; O.T. Raitakari; S. Hägg; N.L. Pedersen; K.H. Herzig; M.R. Järvelin; J. Veijola; M. Kivimaki; R. Jorde; H. Brenner; M. Kumari; C. Power; D.J. Llewellyn; E. Hyppönen

Vitamin D and cognitive function: A Mendelian randomisation study.

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Date

16 octobre 2017

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Articles

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Anglais

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doi: 10.1038/s41598-017-13189-3
issn: 2045-2322

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-017-13189-3

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/29038561

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2045-2322

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_B3DD05034F899

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/

Mots-clés 0

Aged; Cognition/physiology; Cohort Studies; Female; Humans; Male; Mendelian Randomization Analysis; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Vitamin D/analogs & derivatives; Vitamin D/blood; Vitamin D/physiology; Vitamins/physiology

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Tally sticks Scores Notched sticks Group dynamics Association Groups, Social Sexuality Human sexuality Sexual practices Sexual behavior Human beings--Sexual behavior Gender (Sex) Sex (Gender) Blood--Serum Blood serum Retention (Psychology) Older persons Older adults Seniors (Older people) Elderly people Old people Senior citizens Aging people Aged

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J. Maddock et al., « Vitamin D and cognitive function: A Mendelian randomisation study. », Serveur académique Lausannois, ID : 10.1038/s41598-017-13189-3

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The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p curvature ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.

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Vitamin D and cognitive function: A Mendelian randomisation study.

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