A genome-wide association study of early menopause and the combined impact of identified variants.

J.R. Perry; T. Corre; T. Esko; D.I. Chasman; K. Fischer; N. Franceschini; C. He; Z. Kutalik; M. Mangino; L.M. Rose; A. Vernon Smith; L. Stolk; P. Sulem; M.N. Weedon; W.V. Zhuang; A. Arnold; A. Ashworth; S. Bergmann; J.E. Buring; A. Burri; C. Chen; M.C. Cornelis; D.J. Couper; M.O. Goodarzi; V. Gudnason; T. Harris; A. Hofman; M. Jones; P. Kraft; L. Launer; J.S. Laven; G. Li; B. McKnight; C. Masciullo; L. Milani; N. Orr; B.M. Psaty; P.M. Ridker; F. Rivadeneira; C. Sala; A. Salumets; M. Schoemaker; M. Traglia; G. Waeber; S.J. Chanock; E.W. Demerath; M. Garcia; S.E. Hankinson; F.B. Hu; D.J. Hunter; K.L. Lunetta; A. Metspalu; G.W. Montgomery; J.M. Murabito; A.B. Newman; K.K. Ong; T.D. Spector; K. Stefansson; A.J. Swerdlow; U. Thorsteinsdottir; R.M. Van Dam; A.G. Uitterlinden; J.A. Visser; P. Vollenweider; D. Toniolo; A. Murray

A genome-wide association study of early menopause and the combined impact of identified variants.

Fiche du document

Auteurs

Date

2013

Discipline

Anthropologie biologique

Type de document

Articles

Périmètre

Publications

Langue

Anglais

Identifiants

doi: 10.1093/hmg/dds551
issn: 0964-6906

Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1093/hmg/dds551

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/23307926

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1460-2083

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_1B48C9EEEFB75

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Sujets proches En

Female climacteric Female change of life Change of life in women

Citer ce document

J.R. Perry et al., « A genome-wide association study of early menopause and the combined impact of identified variants. », Serveur académique Lausannois, ID : 10.1093/hmg/dds551

Partage / Export

Résumé 0

Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan considerably. Currently, it constitutes the leading cause of infertility in the western world, affecting mainly those women who postpone their first pregnancy beyond the age of 30 years. The genetic aetiology of EM is largely unknown in the majority of cases. We have undertaken a meta-analysis of genome-wide association studies (GWASs) in 3493 EM cases and 13 598 controls from 10 independent studies. No novel genetic variants were discovered, but the 17 variants previously associated with normal age at natural menopause as a quantitative trait (QT) were also associated with EM and primary ovarian insufficiency (POI). Thus, EM has a genetic aetiology which overlaps variation in normal age at menopause and is at least partly explained by the additive effects of the same polygenic variants. The combined effect of the common variants captured by the single nucleotide polymorphism arrays was estimated to account for ∼30% of the variance in EM. The association between the combined 17 variants and the risk of EM was greater than the best validated non-genetic risk factor, smoking.

{"uri":"10.1093\/hmg\/dds551","creators":[{"id":"perry_j_r","lastname":"Perry"},{"id":"corre_t","lastname":"Corre"},{"id":"esko_t","lastname":"Esko"},{"id":"chasman_d_i","lastname":"Chasman"},{"id":"fischer_k","lastname":"Fischer"},{"id":"franceschini_n","lastname":"Franceschini"},{"id":"he_c","lastname":"He"},{"id":"kutalik_z","lastname":"Kutalik"},{"id":"mangino_m","lastname":"Mangino"},{"id":"rose_l_m","lastname":"Rose"},{"id":"vernon_smith_a","lastname":"Vernon Smith"},{"id":"stolk_l","lastname":"Stolk"},{"id":"sulem_p","lastname":"Sulem"},{"id":"weedon_m_n","lastname":"Weedon"},{"id":"zhuang_w_v","lastname":"Zhuang"},{"id":"arnold_a","lastname":"Arnold"},{"id":"ashworth_a","lastname":"Ashworth"},{"id":"bergmann_s","lastname":"Bergmann"},{"id":"buring_j_e","lastname":"Buring"},{"id":"burri_a","lastname":"Burri"},{"id":"chen_c","lastname":"Chen"},{"id":"cornelis_m_c","lastname":"Cornelis"},{"id":"couper_d_j","lastname":"Couper"},{"id":"goodarzi_m_o","lastname":"Goodarzi"},{"id":"gudnason_v","lastname":"Gudnason"},{"id":"harris_t","lastname":"Harris"},{"id":"hofman_a","lastname":"Hofman"},{"id":"jones_m","lastname":"Jones"},{"id":"kraft_p","lastname":"Kraft"},{"id":"launer_l","lastname":"Launer"},{"id":"laven_j_s","lastname":"Laven"},{"id":"li_g","lastname":"Li"},{"id":"mcknight_b","lastname":"McKnight"},{"id":"masciullo_c","lastname":"Masciullo"},{"id":"milani_l","lastname":"Milani"},{"id":"orr_n","lastname":"Orr"},{"id":"psaty_b_m","lastname":"Psaty"},{"id":"ridker_p_m","lastname":"Ridker"},{"id":"rivadeneira_f","lastname":"Rivadeneira"},{"id":"sala_c","lastname":"Sala"},{"id":"salumets_a","lastname":"Salumets"},{"id":"schoemaker_m","lastname":"Schoemaker"},{"id":"traglia_m","lastname":"Traglia"},{"id":"waeber_g","lastname":"Waeber"},{"id":"chanock_s_j","lastname":"Chanock"},{"id":"demerath_e_w","lastname":"Demerath"},{"id":"garcia_m","lastname":"Garcia"},{"id":"hankinson_s_e","lastname":"Hankinson"},{"id":"hu_f_b","lastname":"Hu"},{"id":"hunter_d_j","lastname":"Hunter"},{"id":"lunetta_k_l","lastname":"Lunetta"},{"id":"metspalu_a","lastname":"Metspalu"},{"id":"montgomery_g_w","lastname":"Montgomery"},{"id":"murabito_j_m","lastname":"Murabito"},{"id":"newman_a_b","lastname":"Newman"},{"id":"ong_k_k","lastname":"Ong"},{"id":"spector_t_d","lastname":"Spector"},{"id":"stefansson_k","lastname":"Stefansson"},{"id":"swerdlow_a_j","lastname":"Swerdlow"},{"id":"thorsteinsdottir_u","lastname":"Thorsteinsdottir"},{"id":"van_dam_r_m","lastname":"Van Dam"},{"id":"uitterlinden_a_g","lastname":"Uitterlinden"},{"id":"visser_j_a","lastname":"Visser"},{"id":"vollenweider_p","lastname":"Vollenweider"},{"id":"toniolo_d","lastname":"Toniolo"},{"id":"murray_a","lastname":"Murray"}]}

Par les mêmes auteurs

{"uri":"10.1093\/hmg\/dds551","titles":["A genome-wide association study of early menopause and the combined impact of identified variants."],"disciplines":[{"uri":"http:\/\/aurehal.archives-ouvertes.fr\/subject\/shs.anthro-bio","label":{"fr":"Anthropologie biologique","es":"Antropolog\u00eda biol\u00f3gica","en":"Biological anthropology"}}],"creators":[{"id":"perry_j_r","lastname":"Perry"},{"id":"corre_t","lastname":"Corre"},{"id":"esko_t","lastname":"Esko"},{"id":"chasman_d_i","lastname":"Chasman"},{"id":"fischer_k","lastname":"Fischer"},{"id":"franceschini_n","lastname":"Franceschini"},{"id":"he_c","lastname":"He"},{"id":"kutalik_z","lastname":"Kutalik"},{"id":"mangino_m","lastname":"Mangino"},{"id":"rose_l_m","lastname":"Rose"},{"id":"vernon_smith_a","lastname":"Vernon Smith"},{"id":"stolk_l","lastname":"Stolk"},{"id":"sulem_p","lastname":"Sulem"},{"id":"weedon_m_n","lastname":"Weedon"},{"id":"zhuang_w_v","lastname":"Zhuang"},{"id":"arnold_a","lastname":"Arnold"},{"id":"ashworth_a","lastname":"Ashworth"},{"id":"bergmann_s","lastname":"Bergmann"},{"id":"buring_j_e","lastname":"Buring"},{"id":"burri_a","lastname":"Burri"},{"id":"chen_c","lastname":"Chen"},{"id":"cornelis_m_c","lastname":"Cornelis"},{"id":"couper_d_j","lastname":"Couper"},{"id":"goodarzi_m_o","lastname":"Goodarzi"},{"id":"gudnason_v","lastname":"Gudnason"},{"id":"harris_t","lastname":"Harris"},{"id":"hofman_a","lastname":"Hofman"},{"id":"jones_m","lastname":"Jones"},{"id":"kraft_p","lastname":"Kraft"},{"id":"launer_l","lastname":"Launer"},{"id":"laven_j_s","lastname":"Laven"},{"id":"li_g","lastname":"Li"},{"id":"mcknight_b","lastname":"McKnight"},{"id":"masciullo_c","lastname":"Masciullo"},{"id":"milani_l","lastname":"Milani"},{"id":"orr_n","lastname":"Orr"},{"id":"psaty_b_m","lastname":"Psaty"},{"id":"ridker_p_m","lastname":"Ridker"},{"id":"rivadeneira_f","lastname":"Rivadeneira"},{"id":"sala_c","lastname":"Sala"},{"id":"salumets_a","lastname":"Salumets"},{"id":"schoemaker_m","lastname":"Schoemaker"},{"id":"traglia_m","lastname":"Traglia"},{"id":"waeber_g","lastname":"Waeber"},{"id":"chanock_s_j","lastname":"Chanock"},{"id":"demerath_e_w","lastname":"Demerath"},{"id":"garcia_m","lastname":"Garcia"},{"id":"hankinson_s_e","lastname":"Hankinson"},{"id":"hu_f_b","lastname":"Hu"},{"id":"hunter_d_j","lastname":"Hunter"},{"id":"lunetta_k_l","lastname":"Lunetta"},{"id":"metspalu_a","lastname":"Metspalu"},{"id":"montgomery_g_w","lastname":"Montgomery"},{"id":"murabito_j_m","lastname":"Murabito"},{"id":"newman_a_b","lastname":"Newman"},{"id":"ong_k_k","lastname":"Ong"},{"id":"spector_t_d","lastname":"Spector"},{"id":"stefansson_k","lastname":"Stefansson"},{"id":"swerdlow_a_j","lastname":"Swerdlow"},{"id":"thorsteinsdottir_u","lastname":"Thorsteinsdottir"},{"id":"van_dam_r_m","lastname":"Van Dam"},{"id":"uitterlinden_a_g","lastname":"Uitterlinden"},{"id":"visser_j_a","lastname":"Visser"},{"id":"vollenweider_p","lastname":"Vollenweider"},{"id":"toniolo_d","lastname":"Toniolo"},{"id":"murray_a","lastname":"Murray"}]}

A genome-wide association study of early menopause and the combined impact of identified variants.

Fiche du document

Sujets proches En

Citer ce document

Métriques

Partage / Export

Résumé 0

Par les mêmes auteurs

Sur les mêmes sujets

Sur les mêmes disciplines

Exporter en