Time-dependent lipid profile inversely associates with mortality in hemodialysis patients - independent of inflammation/malnutrition.
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- doi: 10.1111/joim.13291
- issn: 0954-6820
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info:eu-repo/semantics/altIdentifier/pmid/33998741
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E998B78F735B4
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Patients--Mortality Mortality, Law ofCiter ce document
T. Ebert et al., « Time-dependent lipid profile inversely associates with mortality in hemodialysis patients - independent of inflammation/malnutrition. », Serveur académique Lausannois, ID : 10.1111/joim.13291
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Patients with end-stage kidney disease have an extremely high cardiovascular mortality rate, but there is a paradoxical relationship between lipid profile and survival in haemodialysis patients. To investigate whether inflammation/malnutrition confounds the associations between lipids and mortality, we studied a full lipid profile comprising of five clinically well-established lipid parameters and its associations with mortality in a large, multinational European cohort with a median follow-up >3 years. The association between quartiles of total, high-density lipoprotein (HDL), non-HDL, low-density lipoprotein (LDL) cholesterol, as well as triglyceride, levels and the end-points of all-cause, cardiovascular and non-cardiovascular mortality was assessed in a cohort of 5,382 incident, adult haemodialysis patients from >250 Fresenius Medical Care dialysis centres out of 14 participating countries using baseline and time-dependent Cox models. Analyses were fully adjusted and stratified for inflammation/malnutrition status and other patient-level variables. Time-dependent quartiles of total, HDL, non-HDL and LDL cholesterol were inversely associated with the hazard for all-cause, cardiovascular and non-cardiovascular mortality. Compared with the lowest quartile of the respective lipid parameter, hazard ratios of other quartiles were