Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.

R.W. Morris; A.E. Taylor; M.E. Fluharty; J.H. Bjørngaard; B.O. Åsvold; M. Elvestad Gabrielsen; A. Campbell; R. Marioni; M. Kumari; T. Korhonen; S. Männistö; P. Marques-Vidal; M. Kaakinen; A. Cavadino; I. Postmus; L.L. Husemoen; T. Skaaby; T.V. Ahluwalia; J.L. Treur; G. Willemsen; C. Dale; S.G. Wannamethee; J. Lahti; A. Palotie; K. Räikkönen; A. McConnachie; S. Padmanabhan; A. Wong; C. Dalgård; L. Paternoster; Y. Ben-Shlomo; J. Tyrrell; J. Horwood; D.M. Fergusson; M.A. Kennedy; E.A. Nohr; L. Christiansen; K.O. Kyvik; D. Kuh; G. Watt; J.G. Eriksson; P.H. Whincup; J.M. Vink; D.I. Boomsma; G. Davey Smith; D. Lawlor; A. Linneberg; I. Ford; J.W. Jukema; C. Power; E. Hyppönen; M.R. Jarvelin; M. Preisig; K. Borodulin; J. Kaprio; M. Kivimaki; B.H. Smith; C. Hayward; P.R. Romundstad; T.I. Sørensen; M.R. Munafò; N. Sattar

Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.

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2015

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Anglais

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doi: 10.1136/bmjopen-2015-008808

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Serveur académique Lausannois

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info:eu-repo/semantics/altIdentifier/doi/10.1136/bmjopen-2015-008808

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info:eu-repo/semantics/altIdentifier/pmid/26264275

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info:eu-repo/semantics/altIdentifier/eissn/2044-6055

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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_9CE30F110D2A3

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Adolescent; Adult; Aged; Body Mass Index; Female; Humans; Male; Mendelian Randomization Analysis; Middle Aged; Obesity, Abdominal/complications; Sex Factors; Smoking/adverse effects; Smoking/genetics; Waist Circumference; Waist-Hip Ratio; Young Adult

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Fatness Corpulence Overweight Adiposity

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R.W. Morris et al., « Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. », Serveur académique Lausannois, ID : 10.1136/bmjopen-2015-008808

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OBJECTIVES: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity. DESIGN: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes. PARTICIPANTS: 148,731 current, former and never-smokers of European ancestry aged ≥ 16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA). PRIMARY OUTCOME MEASURES: Waist and hip circumferences, and waist-hip ratio. RESULTS: The data included up to 66,809 never-smokers, 43,009 former smokers and 38,913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% CI -0.57% to -0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% CI -0.42% to -0.19), -0.08% (-0.19% to 0.03%) and -0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele. CONCLUSIONS: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.

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Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.

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