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2015
- doi: 10.1136/gutjnl-2013-306287
- issn: 0017-5749
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info:eu-repo/semantics/altIdentifier/doi/10.1136/gutjnl-2013-306287
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info:eu-repo/semantics/altIdentifier/pmid/24996883
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info:eu-repo/semantics/altIdentifier/eissn/1468-3288
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_0BC295BFB7806
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
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K. Fitzmaurice et al., « Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection. », Serveur académique Lausannois, ID : 10.1136/gutjnl-2013-306287
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BACKGROUND: Chronic HCV infection is a leading cause of liver-related morbidity globally. The innate and adaptive immune responses are thought to be important in determining viral outcomes. Polymorphisms associated with the IFNL3 (IL28B) gene are strongly associated with spontaneous clearance and treatment outcomes. OBJECTIVE: This study investigates the importance of HLA genes in the context of genetic variation associated with the innate immune genes IFNL3 and KIR2DS3. DESIGN: We assess the collective influence of HLA and innate immune genes on viral outcomes in an Irish cohort of women (n=319) who had been infected from a single source as well as a more heterogeneous cohort (Swiss Cohort, n=461). In the Irish cohort, a number of HLA alleles are associated with different outcomes, and the impact of IFNL3-linked polymorphisms is profound. RESULTS: Logistic regression was performed on data from the Irish cohort, and indicates that the HLA-A*03 (OR 0.36 (0.15 to 0.89), p=0.027) -B*27 (OR 0.12 (0.03 to 0.45), p=