Fiche du document
- doi: 10.1371/journal.pcbi.1007162
- issn: 1553-734X
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pcbi.1007162
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/31269015
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1553-7358
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_DB3E6C72F6748
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
Sujets proches
Ageing Senescence Age--Physiological effectCiter ce document
A. Komljenovic et al., « Cross-species functional modules link proteostasis to human normal aging. », Serveur académique Lausannois, ID : 10.1371/journal.pcbi.1007162
Métriques
Partage / Export
Résumé
The evolutionarily conserved nature of the few well-known anti-aging interventions that affect lifespan, such as caloric restriction, suggests that aging-related research in model organisms is directly relevant to human aging. Since human lifespan is a complex trait, a systems-level approach will contribute to a more comprehensive understanding of the underlying aging landscape. Here, we integrate evolutionary and functional information of normal aging across human and model organisms at three levels: gene-level, process-level, and network-level. We identify evolutionarily conserved modules of normal aging across diverse taxa, and notably show proteostasis to be conserved in normal aging. Additionally, we find that mechanisms related to protein quality control network are enriched for genes harboring genetic variants associated with 22 age-related human traits and associated to caloric restriction. These results demonstrate that a systems-level approach, combined with evolutionary conservation, allows the detection of candidate aging genes and pathways relevant to human normal aging.