Long-term trends in mortality and AIDS-defining events after combination ART initiation among children and adolescents with perinatal HIV infection in 17 middle- and high-income countries in Europe and Thailand: A cohort study
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30 janvier 2018
info:eu-repo/semantics/openAccess , http://creativecommons.org/licenses/by/
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ADOLESCENTS YOUTHS CENTRAL_AND_EASTERN_EUROPE PERINATAL_MORTALITY WESTERN_EUROPE CHILDREN THAILAND AIDS CHILD_MORTALITYSujets proches
Childhood Youngsters Pedology (Child study) Kids (Children)Citer ce document
The European Pregnancy and Paediatric HIV Cohort Collaboration (EPPICC) study group in EuroCoord et al., « Long-term trends in mortality and AIDS-defining events after combination ART initiation among children and adolescents with perinatal HIV infection in 17 middle- and high-income countries in Europe and Thailand: A cohort study », Archined : l'archive ouverte de l'INED, ID : 10.1371/journal.pmed.1002491
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BACKGROUND: Published estimates of mortality and progression to AIDS as children with HIV approach adulthood are limited. We describe rates and risk factors for death and AIDS-defining events in children and adolescents after initiation of combination antiretroviral therapy (cART) in 17 middle- and high-income countries, including some in Western and Central Europe (W&CE), Eastern Europe (Russia and Ukraine), and Thailand. METHODS AND FINDINGS: Children with perinatal HIV aged 6 months of cART) death and progression to AIDS were assessed. Of 3,526 children included, 32% were from the United Kingdom or Ireland, 30% from elsewhere in W&CE, 18% from Russia or Ukraine, and 20% from Thailand. At cART initiation, median age was 5.2 (IQR 1.4-9.3) years; 35% of children aged