Genetic loci for retinal arteriolar microcirculation.

X. Sim; R.A. Jensen; M.K. Ikram; M.F. Cotch; X. Li; S. MacGregor; J. Xie; A.V. Smith; E. Boerwinkle; P. Mitchell; R. Klein; B.E. Klein; N.L. Glazer; T. Lumley; B. McKnight; B.M. Psaty; P.T. de Jong; A. Hofman; F. Rivadeneira; A.G. Uitterlinden; C.M. van Duijn; T. Aspelund; G. Eiriksdottir; T.B. Harris; F. Jonasson; L.J. Launer; J. Attia; P.N. Baird; S. Harrap; E.G. Holliday; M. Inouye; E. Rochtchina; R.J. Scott; A. Viswanathan; G. Li; N.L. Smith; K.L. Wiggins; J.Z. Kuo; K.D. Taylor; A.W. Hewitt; N.G. Martin; G.W. Montgomery; C. Sun; T.L. Young; D.A. Mackey; N.R. van Zuydam; A.S. Doney; C.N. Palmer; A.D. Morris; J.I. Rotter; E.S. Tai; V. Gudnason; J.R. Vingerling; D.S. Siscovick; J.J. Wang; T.Y. Wong

Genetic loci for retinal arteriolar microcirculation.

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Date

2013

Discipline

Anthropologie biologique

Type de document

Articles

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Publications

Langue

Anglais

Identifiants

doi: 10.1371/journal.pone.0065804
issn: 1932-6203

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0065804

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/23776548

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1932-6203

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_8E9B6F79BB0A1

Collection

Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC0 1.0 , https://creativecommons.org/publicdomain/zero/1.0/

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X. Sim et al., « Genetic loci for retinal arteriolar microcirculation. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0065804

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Narrow arterioles in the retina have been shown to predict hypertension as well as other vascular diseases, likely through an increase in the peripheral resistance of the microcirculatory flow. In this study, we performed a genome-wide association study in 18,722 unrelated individuals of European ancestry from the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium and the Blue Mountain Eye Study, to identify genetic determinants associated with variations in retinal arteriolar caliber. Retinal vascular calibers were measured on digitized retinal photographs using a standardized protocol. One variant (rs2194025 on chromosome 5q14 near the myocyte enhancer factor 2C MEF2C gene) was associated with retinal arteriolar caliber in the meta-analysis of the discovery cohorts at genome-wide significance of P-value

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Genetic loci for retinal arteriolar microcirculation.

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