Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.

J.A. Nettleton; N.M. McKeown; S. Kanoni; R.N. Lemaitre; M.F. Hivert; J. Ngwa; F.J. van Rooij; E. Sonestedt; M.K. Wojczynski; Z. Ye; T. Tanaka; M. Garcia; J.S. Anderson; J.L. Follis; L. Djousse; K. Mukamal; C. Papoutsakis; D. Mozaffarian; M.C. Zillikens; S. Bandinelli; A.J. Bennett; I.B. Borecki; M.F. Feitosa; L. Ferrucci; N.G. Forouhi; C.J. Groves; G. Hallmans; T. Harris; A. Hofman; D.K. Houston; F.B. Hu; I. Johansson; S.B. Kritchevsky; C. Langenberg; L. Launer; Y. Liu; R.J. Loos; M. Nalls; M. Orho-Melander; F. Renstrom; K. Rice; U. Riserus; O. Rolandsson; J.I. Rotter; G. Saylor; E.J. Sijbrands; P. Sjogren; A. Smith; L. Steingrímsdóttir; A.G. Uitterlinden; N.J. Wareham; I. Prokopenko; J.S. Pankow; C.M. van Duijn; J.C. Florez; J.C. Witteman; J. Dupuis; G.V. Dedoussis; J.M. Ordovas; E. Ingelsson; L. Cupples; D.S. Siscovick; P.W. Franks; J.B. Meigs

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.

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Anthropologie biologique

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Anglais

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doi: 10.2337/dc10-1150
issn: 0149-5992

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Serveur académique Lausannois

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info:eu-repo/semantics/altIdentifier/doi/10.2337/dc10-1150

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info:eu-repo/semantics/altIdentifier/pmid/20693352

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info:eu-repo/semantics/altIdentifier/eissn/1935-5548

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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_C905D0EAEA857

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Adult; Aged; Blood Glucose/genetics; Blood Glucose/metabolism; Edible Grain; European Continental Ancestry Group; Fasting/blood; Female; Genetic Loci/genetics; Genome-Wide Association Study; Genotype; Humans; Insulin/blood; Insulin/genetics; Male; Middle Aged; Polymorphism, Single Nucleotide/genetics

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J.A. Nettleton et al., « Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. », Serveur académique Lausannois, ID : 10.2337/dc10-1150

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Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin. Via meta-analysis of data from 14 cohorts comprising ∼ 48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value

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Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.

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