Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort.

S. Westwood; A.L. Baird; S.N. Anand; A.J. Nevado-Holgado; A. Kormilitzin; L. Shi; A. Hye; N.J. Ashton; A.R. Morgan; I. Bos; SJB Vos; S. Baker; N.J. Buckley; M. Ten Kate; P. Scheltens; C.E. Teunissen; R. Vandenberghe; S. Gabel; K. Meersmans; S. Engelborghs; E.E. De Roeck; K. Sleegers; G.B. Frisoni; O. Blin; J.C. Richardson; R. Bordet; J.L. Molinuevo; L. Rami; A. Wallin; P. Kettunen; M. Tsolaki; F. Verhey; A. Lléo; I. Sala; J. Popp; G. Peyratout; P. Martinez-Lage; M. Tainta; P. Johannsen; Y. Freund-Levi; L. Frölich; V. Dobricic; C. Legido-Quigley; L. Bertram; F. Barkhof; H. Zetterberg; B.P. Morgan; J. Streffer; P.J. Visser; S. Lovestone

Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort.

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Date

2020

Discipline

Psychologie

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Articles

Périmètre

Publications

Langue

Anglais

Identifiants

doi: 10.3233/JAD-190434
issn: 1387-2877

Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.3233/JAD-190434

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/31985466

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1875-8908

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_24E3A61BAA924

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , CC BY-NC 4.0 , https://creativecommons.org/licenses/by-nc/4.0/

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Alzheimer’s disease; amyloid-β; biomarkers; plasma; proteomics

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Proteids Disease (Pathology) Biologic markers Biological markers Biomarkers Markers, Biochemical

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S. Westwood et al., « Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort. », Serveur académique Lausannois, ID : 10.3233/JAD-190434

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We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. This study sought to undertake validation of these candidate plasma biomarkers in a large, multi-center sample collection. Targeted plasma analyses of 34 proteins with prior evidence for prediction of in vivo pathology were conducted in up to 1,000 samples from cognitively healthy elderly individuals, people with mild cognitive impairment, and in patients with AD-type dementia, selected from the EMIF-AD catalogue. Proteins were measured using Luminex xMAP, ELISA, and Meso Scale Discovery assays. Seven proteins replicated in their ability to predict in vivo amyloid pathology. These proteins form a biomarker panel that, along with age, could significantly discriminate between individuals with high and low amyloid pathology with an area under the curve of 0.74. The performance of this biomarker panel remained consistent when tested in apolipoprotein E ɛ4 non-carrier individuals only. This blood-based panel is biologically relevant, measurable using practical immunocapture arrays, and could significantly reduce the cost incurred to clinical trials through screen failure.

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Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort.

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