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5 juin 2021
- doi: 10.3390/dermatopathology8020023
- issn: 2296-3529
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info:eu-repo/semantics/altIdentifier/doi/10.3390/dermatopathology8020023
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info:eu-repo/semantics/altIdentifier/pmid/34198758
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info:eu-repo/semantics/altIdentifier/pissn/2296-3529
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_93707AA3906A3
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
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Melanocytic tumor Malignant melanomaCiter ce document
A. Stahl et al., « 5-Hydroxymethylcytosine Loss in Conjunctival Melanoma. », Serveur académique Lausannois, ID : 10.3390/dermatopathology8020023
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Conjunctival and cutaneous melanoma partially share similar clinical and molecular backgrounds. As 5-hydroxymethylcytosine (5-hmC) loss has been demonstrated in cutaneous melanoma, we decided to assess if similar changes were occurring in conjunctival melanoma. 5-methylcytosine (5-mC), 5-hmC and TET2 were respectively identified by immunohistochemistry and RNA ISH in 40 conjunctival nevi and 37 conjunctival melanomas. Clinicopathological correlations were established. 5-mC, TET2 and 5-hmC were respectively identified in 67.5%, 95% and 100% of conjunctival nevi and in 81.1%, 35.1% and 54% of conjunctival melanomas. A significant 5-hmC and TET2 loss was identified in conjunctival melanoma comparing to nevus, as well as a significant correlation between TET2 and 5-hmC expression. In the melanomas, 5-hmC expression was only significantly associated with local lymphatic invasion, but not with other clinicopathological parameters. There was a correlation between TET2 expression and the localization of the tumors. 5-mC expression was not associated with any clinicopathological parameters. We identified a significant 5-hmC loss in conjunctival melanoma similar to cutaneous melanoma. This loss may possibly be attributed to TET2 loss or IDH1 mutations. 5-hmC loss in conjunctival melanoma may help in the differential diagnosis between atypical conjunctival nevus and conjunctival melanoma.