A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control.
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2013
- doi: 10.7554/eLife.01123
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I. Bartha et al., « A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control. », Serveur académique Lausannois, ID : 10.7554/eLife.01123
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HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 sequence variation and plasma viral load (VL), while considering human and viral population structure. We observed significant human SNP associations to a total of 48 HIV-1 amino acid variants (p