Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity
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2006
- handle: 10670/1.50xeyo
- hal: hal-01076821
- doi: 10.1084/jem/20061640
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info:eu-repo/semantics/altIdentifier/doi/10.1084/jem/20061640
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Vanin-1 licenses infl ammatory mediatorSujets proches
Permits Licenses--Law and legislation Licences Colonitis Colon (Anatomy)--InflammationCiter ce document
Carole Berruyer et al., « Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor γ activity », Archive Ouverte d'INRAE, ID : 10.1084/jem/20061640
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Colitis involves immune cell–mediated tissue injuries, but the contribution of epithelial cells remains largely unclear. Vanin-1 is an epithelial ectoenzyme with a pantetheinase activity that provides cysteamine/cystamine to tissue. Using the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-colitis model we show here that Vanin-1 deficiency protects from colitis. This protection is reversible by administration of cystamine or bisphenol A diglycidyl ether, a peroxisome proliferator-activated receptor (PPAR)후 antagonist. We further demonstrate that Vanin-1, by antagonizing PPAR 후, licenses the production of inflammatory mediators by intestinal epithelial cells. We propose that Vanin-1 is an epithelial sensor of stress that exerts a dominant control over innate immune responses in tissue. Thus, the Vanin-1/ pantetheinase activity might be a new target for therapeutic intervention in inflammatory bowel disease.