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- handle: 10670/1.szapcp
- hal: hal-01964545
- doi: 10.1016/j.trecan.2018.10.002
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.trecan.2018.10.002
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info:eu-repo/grantAgreement//637647/EU/Immunity, DEvelopment and Microbiota: Understanding the Continuous Construction of Biological Identity/IDEM
info:eu-repo/semantics/OpenAccess
Mots-clés
immune system angiogenesis niche tumor organismal environment Tumor microenvironment -bio] -bio]/Cancer -bio]/Development Biology -bio]/Ecology, environment -bio]/ImmunologySujets proches
Natural science Sciences Science of scienceCiter ce document
Lucie Laplane et al., « The Multiple Layers of the Tumor Environment », HAL-SHS : histoire, philosophie et sociologie des sciences et des techniques, ID : 10.1016/j.trecan.2018.10.002
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The notion of tumor microenvironment (TME) has been brought to the forefront of recent scientific literature on cancer. However, there is no consensus on how to define and spatially delineate the TME. We propose that the time is ripe to go beyond an all-encompassing list of the components of the TME, and to construct a multilayered view of cancer. We distinguish six layers of environmental interactions with the tumor and show that they are associated with distinct mechanisms, and ultimately with distinct therapeutic approaches.