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2021
- handle: 10670/1.ynz58o
- hal: hal-03483878
- doi: 10.1136/thoraxjnl-2021-217870
- PUBMED: 34675126
- WOS: 000728110400001
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info:eu-repo/semantics/altIdentifier/doi/10.1136/thoraxjnl-2021-217870
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info:eu-repo/semantics/altIdentifier/pmid/34675126
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info:eu-repo/grantAgreement/EC/FP7/295449/EU/Darwinism and the Theory of Rational Choice/DARTCH
http://creativecommons.org/licenses/by/ , info:eu-repo/semantics/OpenAccess
Mots-clés
occupational lung disease paediatric interstitial lung disease rare lung diseases sarcoidosis -bio]Sujets proches
Boeck's sarcoid Schaumann's disease Granuloma benignum Lymphogranulomatosis benigna Besnier-Boeck diseaseCiter ce document
Nadia Nathan et al., « Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study », Archive ouverte de Sciences Po (SPIRE), ID : 10.1136/thoraxjnl-2021-217870
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Résumé
Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5-7) vs 0.5 (0-2), p=0.003 and 1 (0-2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.