Proliferative and necrotizing otitis externa (PNOE) is a rare dermatitis with unknown etiology affecting kittens between 2 to 6-months-old and adult cats. Its clinical signs are unique and diagnosis is based on skin histopathology. Lesions develop rapidly and in kittens may regress spontaneously. A...
Introduction: Patient-Reported Outcomes (PRO) integrate a wide range of holistic dimensions that arenot captured within clinical outcomes. Particularly, from induction treatment to maintenance therapy, patient quality-of-life (QoL) of kidney transplant recipients have been sparsely investigated in i...
Le dosage et le suivi des taux plasmatiques de triglycérides (TG) sont essentiels dans les unités de soins intensifs (USI), notamment pour gérer le risque de pancréatite induite par le propofol. Cependant, l’utilisation de certaines thérapeutiques en USI telle que l’administration intraveineuse d’ac...
Sustained ryanodine receptor (RyR) Ca 2+ leak is associated with pathological conditions such as heart failure or skeletal muscle weakness. We report that a single session of sprint interval training (SIT), but not of moderate intensity continuous training (MICT), triggers RyR1 protein oxidation and...
Primary maintenance immunosuppressive therapies for renal transplant recipients underwent significant changes in recent years. We aimed to assess time trends and the impact of immunosuppressive regimens in first renal transplant recipients without immunological risk (blood group incompatibility, pre...
Systematic analyses of inflammatory bowel disease (IBD) drug-related side effects necessitating treatment cessation in large cohorts of patients with IBD are scarce. We aimed to assess the frequency and type of drug-related side effects requiring drug cessation in patients included in the Swiss IBD...
An important feature of type 2 diabetes is a decrease in β -cell mass. Therefore, it is essential to find new approaches to stimulate β -cell proliferation. We have previously shown that heterozygous inactivation of the Na + /Ca 2+ exchanger (isoform 1; NCX1), a protein responsible for Ca 2+ extrusi...
To σύνδρομο της δερματίτιδας από λείξη των άκρων σε σκύλους είναι ένα από τα πιο περίπλοκα δερματολογικά προβλήματα, που καλείται να αντιμετωπίσει ο κτηνίατρος στην καθημερινή πράξη. Οι δερματικές αλλοιώσεις είναι το αποτέλεσμα της επίμονης λείξης κάποιας συγκεκριμένης περιοχής, συνήθως στην πρόσθια...
Resumen El primer trasplante de intestino exitoso realizado en humanos se llevó a cabo en 1988, en Alemania, por el Dr. Deltz. Sin embargo, no es hasta diciembre de 2013, cuando en Costa Rica, en el hospital “Dr. Rafael Ángel Calderón Guardia”, se efectúa el primer trasplante humano de intestino del...
Metabolic syndrome after transplantation is a major concern following solid organ transplantation (SOT). The CREB-regulated transcription co-activator 2 (CRTC2) regulates glucose metabolism. The effect of CRTC2 polymorphisms on new-onset diabetes after transplantation (NODAT) was investigated in a d...
Lack of adherence to medication is a trigger of graft rejection in solid-organ transplant (SOT) recipients. This exploratory study aimed to assess whether a biopsychosocial evaluation using the INTERMED instrument before transplantation could identify SOT recipients at risk of suboptimal post-transp...
3. Abstract Introduction: Des multiples études chez des patients après transplantation rénale ou hépatique indiquent des conséquences possibles d’un Coefficient de Variation (CV) du taux de tacrolimus élevé. Cependant, il y a très peu d’études qui se sont intéressées à ce sujet chez les patients tra...
OBJECTIVES: Invasive mould infections are associated with a high mortality rate and the emergence of MDR moulds is of particular concern. Calcineurin and its chaperone, the heat shock protein 90 (Hsp90), represent an important pathway for fungal virulence that can be targeted at different levels. We...
"OBJECTIVE: To analyze the cost-effectiveness of treatment regimens with cyclosporine or tacrolimus, five years after renal transplantation.METHODS: This cost-effectiveness analysis was based on historical cohort data obtained between 2000 and 2004 and involved 2,022 patients treated with cyclospori...