Les anti-TNF-α pour le traitement des uvéites non infectieuses [Anti-TNF-α in the treatment of non-infectious uveitis]
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- doi: 10.1051/medsci/2020160
- issn: 0767-0974
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Uvea--InflammationCite this document
F. Hoogewoud et al., « Les anti-TNF-α pour le traitement des uvéites non infectieuses [Anti-TNF-α in the treatment of non-infectious uveitis] », Serveur académique Lausannois, ID : 10.1051/medsci/2020160
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Abstract
Non-infectious uveitis is a heterogenous group of potentially blinding ocular autoimmune diseases that may represent a manifestation of a systemic condition or may affect the eyes only. A systemically administered anti-TNF has recently been approved for the treatment of non-infectious uveitis, broadening the therapeutic arsenal available to control intraocular inflammation and reduce uveitis complications that can lead to vision loss. When uveitis affects only the eyes, a local anti-TNF-α administration strategy could optimize the ocular therapeutic effect and reduce undesirable systemic side-effects. A new ocular method of non-viral gene therapy, currently in development, may broaden the indications for ocular anti-TNF-α agents, not only for uveitis but also for other diseases in which TNF-α-mediated neuro-inflammation has been demonstrated.
