Skin bacterial composition is driven largely by host genetic background and polymorphisms regulating innate immunity.

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January 1, 2017

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https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode


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Integument (Skin) Cutis

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Graeme Walker, « Skin bacterial composition is driven largely by host genetic background and polymorphisms regulating innate immunity. », Open Research Library, ID : 10.26226/morressier.5d4980d28fb7e44098e7322a


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Abstract 0

Skin and wound microbiome have been identified as key modulators of health and disease. Although the general composition of this microbiome follows large trends there are large inter-individual variation. Wound healing is a complex multistep process that involves an inflammatory phase that conditions many of the subsequent stages of healing. Skin barrier rupture results in exposure to bacterial compounds suggesting a key role of the wound microbiome in the healing process.We here aimed to systematically study the skin bacterial composition in normal and wounded animals in 32 different strains of mice from the collaborative cross. The healing speed of excisional wounds varied significantly across strains (P

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