P4-18-05 - Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the milieu intu00e9rieur population of healthy adults

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1 janvier 2017

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https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode



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Valentin Partula, « P4-18-05 - Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the milieu intu00e9rieur population of healthy adults », Open Research Library, ID : 10.26226/morressier.5d5e5189bedcf39b76652856


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IntroductionHost-microbial co-metabolism products are being increasingly recognized to play important roles in physiological processes. Specific classes of molecules and individual metabolic pathways have been functionally characterized. However, studies considering more globally host-microbial metabolic relationships remain scarce. Metabolomic analysis yielding detailed information regarding subtle metabolic interactions holds promise to comprehensively elucidate such interactions. This work aimed to explore the associations between host plasma metabolomic signatures and gut microbiota composition in healthy adults of the Milieu Intu00e9rieur study.Material and MethodsFor 846 subjects, gut microbiota composition was established through sequencing of the 16S rRNA gene in stools. Metabolomic signatures were generated through proton nuclear magnetic resonance analysis of plasma. The associations between metabolomic variables and u03b1- and u03b2-diversity indexes and relative taxa abundances were tested using multi-adjusted partial Spearman correlations, PERMANOVAs, and MaAsLins, respectively. Multiple testing correction was applied (Benjamini-Hochberg, 10%-FDR).ResultsMicrobial richness was negatively associated with lipid-related signals and positively associated with amino acids, choline, creatinine, glucose, and citrate (-0.133 u2264 Spearmanu2019s u03c1 u2264 0.126). Specific associations between metabolomic signals and abundance of taxa were also detected. Notably, strong associations were observed for creatinine, which was positively associated with 11 species and negatively associated with Faecalibacterium prausnitzii.DiscussionThis large-scale population-based study highlights certain metabolites associated with gut microbial features and provides new insights into the understanding of complex host-gut microbiota metabolic relationships. Notably, a role of the gut-kidney axis is suggested. More studies providing a detailed exploration of these complex interactions and their implications for host health are needed.Conflict of interest:There is no conflict of interest.

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