Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study.

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2020

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info:eu-repo/semantics/restrictedAccess , Restricted: indefinite embargo , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/


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Adolescent; Adult; Aged; Aged, 80 and over; Betacoronavirus; COVID-19; Coronavirus Infections/epidemiology; Electronic Health Records; Female; Hospitalization; Hospitals, University; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Pandemics; Pneumonia, Viral/epidemiology; Respiration, Artificial/statistics & numerical data; Retrospective Studies; Risk Factors; SARS-CoV-2; Switzerland; Tertiary Care Centers; Young Adult


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J. Regina et al., « Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss university hospital: An observational retrospective study. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0240781


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This study aims to describe the epidemiology of COVID-19 patients in a Swiss university hospital. This retrospective observational study included all adult patients hospitalized with a laboratory confirmed SARS-CoV-2 infection from March 1 to March 25, 2020. We extracted data from electronic health records. The primary outcome was the need to mechanical ventilation at day 14. We used multivariate logistic regression to identify risk factors for mechanical ventilation. Follow-up was of at least 14 days. 145 patients were included in the multivariate model, of whom 36 (24.8%) needed mechanical ventilation at 14 days. The median time from symptoms onset to mechanical ventilation was 9·5 days (IQR 7.00, 12.75). Multivariable regression showed increased odds of mechanical ventilation with age (OR 1.09 per year, 95% CI 1.03-1.16, p = 0.002), in males (OR 6.99, 95% CI 1.68-29.03, p = 0.007), in patients who presented with a qSOFA score ≥2 (OR 7.24, 95% CI 1.64-32.03, p = 0.009), with bilateral infiltrate (OR 18.92, 3.94-98.23, p

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