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1 janvier 2011
- handle: 10670/1.tjhkr8
Ce document est lié à :
10.5514/rmac.v37.i2.26140
info:eu-repo/semantics/openAccess
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Brain plasticity memory hippocampus Morris water mazeSujets proches
Hippocampus Sea-horse SeahorsesCiter ce document
Montserrat Melgarejo-Gutiérrez et al., « Growth hormone promotes the expression of zif268 gene in the hippocampus », Revista mexicana de análisis de la conducta, ID : 10670/1.tjhkr8
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Résumé
Growth hormone (GH) plays an important role in cognitive processes such as memory consolidation, and it has been suggested that could be involved in processes of brain plasticity. These changes may occur by promoting gene expression in the brain. In this study we showed that GH administration (5ng/kg) for 7 days improves spatial learning and promotes expression of zif268 gene in the rat hippocampus. In addition, a Morris Water Maze (MWM) learning test induced a strong expression of zif268 gene in the hippocampus of adult rats. The effect was even greater when a MWM test and GH were applied together. Our results suggest that GH might be favoring plasticity processes in the hippocampus, by promoting gene expression.