Fiche du document
2003
- doi: 10.1073/pnas.0737244100
- issn: 0027-8424
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.0737244100
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/12676996
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/0027-8424
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_7D14533F6E7F5
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Tumor necrosis factor receptors TNFRs (Tumor necrosis factor receptors) Receptors, Tumor necrosis factor TNF receptors Cachectin receptorsCiter ce document
C.R. Brunetti et al., « A secreted high-affinity inhibitor of human TNF from Tanapox virus. », Serveur académique Lausannois, ID : 10.1073/pnas.0737244100
Métriques
Partage / Export
Résumé
A class of secreted poxvirus tumor necrosis factor (TNF)-binding proteins has been isolated from Tanapox-infected cell supernatants. The inhibitor bound to a TNF-affinity column and was identified as the product of the 2L gene. Sequence analysis of 2L family members from other yatapoxviruses and swinepox virus yielded no sequence homology to any known cellular gene. The expressed Tanapox virus 2L protein bound to human TNF with high affinity (K(d) = 43 pM) and exhibits an unusually slow off-rate. However, 2L is unable to bind to a wide range of human TNF family members. The 2L protein can inhibit human TNF from binding to TNF receptors I and II as well as block TNF-induced cytolysis. Thus, Tanapox virus 2L represents an inhibitor of human TNF and offers a unique strategy with which to modulate TNF activity.