The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non-functional variant in SIGLEC1, which encodes the myeloid-cell receptor Siglec-1/CD169 implicated in HIV-1 cell-to-cell transmission. Here we report a si...

THE PSYCHOEXPOSOME: A HOLISTIC PERSPECTIVE BEYOND HEALTH AND DISEASE.

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María-Teresa Colomina et al. (2018)

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"Background: The concept of the exposome has emerged as a new strategy for studyingallenvironmentalexposuresthroughoutanindividual’slifeand their impact on human health. Nowadays, electronic devices are available to collect data about an individual’s geolocation, biological function, or exposure bio...

Impact of stress in childhood: Psychobiological alterations

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María Banqueri et al. (2017)

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"An extremely high percentage of children worldwide are exposed to stress from the fi rst months of life. The aim of this review is to bring together the experimental results related to chronic early-life stress in both human and experimental models. Methods: We aimed to achieve our objective via a...

Sexual metabolic differences in the rat limbic brain

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Natalia Arias et al. (2013)

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"Background: There is actually limited evidence about the in fl uence of estrogens on neuronal energy metabolism or functional cerebral asymmetry. In order to evaluate this relationship, eight male and sixteen female adult Wistar rats, divided into estrus and diestrus phase, were used to measure bas...

Assessment of the global intelligence and selective cognitive capacities in preterm 8-year-old children

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Azucena Begega et al. (2010)

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"The aim of this study was to assess various cognitive abilities such as attention, IQ, reasoning, and memory related to academic achievement in 8- and 9-year-old preterm children. A total of 141 children were assessed. The preterm group (= 37 weeks) comprised 63 children and was compared to 78 full...

Anxiogenic-like effects of gamma-hydroxybutyric acid (GHB) in mice tested in the light-dark box

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José Francisco Navarro et al. (2008)

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"Gamma-hydroxybutyric acid (GHB) is a drug with abuse potential, popularly known as «liquid ecstasy». It is an endogenous compound of the mammalian brain which satisfies many of the criteria forconsideration as a neurotransmitter or neuromodulator. In this study, the effects of acute administrationo...

Brain c-Fos immunocytochemistry and cytochrome oxidase histochemistry after a fear conditioning task

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Nélida M. Conejo et al. (2007)

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"The involvement of the basolateral and the medial amygdala in fear conditioning was evaluated usingdifferent markers of neuronal activation. The method described here is a combination of cytochromeoxidase (CO) histochemistry and c-Fos immunocytochemistry on fresh frozen brain sections. Freezingbeha...

Alcohol tolerance in rats submitted to different periods of chronic and acute ethanol intake

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Almudena Capilla et al. (2004)

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"The development of tolerance to the effects of ethanol is not uniform and may vary according to theactual and previous pattern of consumption. In this experiment we assessed body temperature and therecovery of two reflexes after a high dose of ethanol in rats submitted to chronic and acute ethanolc...

Sex differences in the Morris water maze in young rats: temporal dimensions

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Jorge L. Arias et al. (2004)

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"There are many factors affecting our memory. The lapse of time between the acquisition and retrievalof information seems to be crucial because the intervening consolidation processes make a lasting engram.In this study, spatial memory was tested in 30day-old male and female Wistar rats by increasin...

Maturation of astrocytes in the rat hippocampus: Potential behavioral implications

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Nélida M. Conejo et al. (2003)

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"Several studies have shown that astroglia plays an important role on the physiology of the central nervoussystem. However, still little research has focused on the analysis of the astroglial population duringthe postnatal development, and the possible influence of biological factors like sex. Using...

Spatial memory and c-fos expression in supramammillary nucleus, anterior cingulated gyrus and entorhinal cortex

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José A. Aguirre et al. (2001)

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"To investigate brain substrates of spatial memory, the cellular expression of c-Fos protein in rats wasstudied after training the animals to perform a spatial reference memory task and a working referencememory task in a Morris water maze. The number of c-Fos positive neuronal nuclei was quantified...

Active avoidance conditioning in rats: absence of sex difference and estrous effect

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Jorge L. Arias et al. (1999)

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"In this paper, possible differences between male and female rats (Rattus norvegicus)in the acquisition and consolidation of 2-way active avoidance learning are studied.In addition to monitoring behavioural parameters (escape and avoidance), the phase ofthe estrous cycle of the female rats was also...

Social isolation and energy metabolism in rat hippocampus

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José M. Cimadevilla et al. (1997)

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The psycho-neuro-immune-endocrine response: a physiological and pathological way of life

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María Soledad Alonso et al. (1996)

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"It is proposed that the response of the organism to injury by mechanical energy is madeup of three consecutive phases: an immediate or nervous phase, an intermediate or immunephase and a late or endocrine phase. The functions that characterize each one of thesethree phases could represent the activ...

Psycho-neuro-immune-endrocrine system behavior in mechanical trauma

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Jaime Arias et al. (1995)

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Brain oxidative metabolism and learning in the morris water maze

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Héctor González Pardo et al. (1995)

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