levure (1) protéine (1) mutation (1) demi-vie (1) dégradation (1) conservation (1) règlement (1) Defects (1) Conservation (1) Agreement (1) Ubiquitin (1) Saccharomyces cerevisiae (1) Yeast (1) Work (1) Relevance (1) Patients (1) Modeling (1) Mental retardation (1) Ligases (1) Identity (Philosophical concept) (1) Face--Abnormalities (1) Evaluation (1) Defects (1) Tax assessment (1) Regulation (1) Residues (1) Positions (1) Patients (1) Mutation (1)