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24 janvier 2025
- 10938/25149
- 2-s2.0-85061157175
Ce document est lié à :
Phytochemistry Letters
Mots-clés
Inflammation Laurenoperoxylide Laurus nobilis Nf-κb Sesquiterpene lactones 1 epi tatridin 11 exo methylenesantonin 3alpha peroxyarmefolin 4alpha hydroxy guaia 10(14),11(13) diene 12,6alpha olide Altissin Armefolin Costunolide Dehydrocostus lactone Eremanthine Germacranolide derivative Immunoglobulin enhancer binding protein Laurenoperoxylide a Laurenoperoxylide b Laurus nobilis extract Magnolialide Maroniolid Parthenolide Plant extract Reynosin Santamarine Sesquiterpene lactone derivative Sivosinolide Spirafolide Tuberiferin Unclassified drug Zaluzanin c Zaluzanin d Animal cell Antiinflammatory activity Article Carbon nuclear magnetic resonance Controlled study Crystal Drug isolation Ic50 Lebanon Monocyte Nonhuman Plant leaf Priority journal Proton nuclear magnetic resonance Raw 264.7 cell line Transcription regulationSujets proches
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Turk et al., « NF-κB inhibitory sesquiterpene lactones from Lebanese Laurus nobilis », American University of Beirut ScholarWorks
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Résumé
The leaves of Laurus nobilis, commonly called as bay leaves, have been traditionally used for the treatment of inflammatory symptoms. As a part of the research on the characterization of bioactive constituents from natural products, twenty one sesquiterpene lactones were isolated from the leaves of L. nobilis. Among them, laurenoperoxylides A (1) and B (2) were first reported in nature and sivosinolide (11), altissin (12), maroniolid (13) and 4α-hydroxy-guaia-10(14), 11(13)-diene-12,6α-olide (20) were first isolated from this plant. The anti-inflammatory activity of isolated compounds was evaluated by measuring their effects on the NF-κB transcriptional activity induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages cells. Among twenty one sesquiterpenes, 11-exo-methylenesantonin (9) exerted the most potent inhibition with an IC 50 value of 4.0 μM. Santamarine (4), magnolialide (5) and zaluzanin D (18) also significantly inhibited NF-κB activity with IC 50 values of
