Early left ventricular remodeling in acute severe aortic regurgitation : insights from an animal model.
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- 20.500.11794/15835
- 0966-8519
- 18592927
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Mots-clés
Aortic regurgitation Left ventricle Remodeling Rat Remodelage ventriculaire Cœur -- Ventricule gauche -- Hypertrophie Rats (Animaux de laboratoire) Cœur -- Valvules -- MaladiesSujets proches
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Dominic Lachance et al., « Early left ventricular remodeling in acute severe aortic regurgitation : insights from an animal model. », CorpusUL, l'archive ouverte de l'université Laval
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Résumé
BACKGROUND AND AIM OF THE STUDY: Chronic aortic regurgitation (AR) induces left ventricular (LV) hypertrophy and eventually LV dysfunction. While the effects of chronic AR on the left ventricle are well known, the effects of acute AR have not been adequately evaluated. It was hypothesized that the LV tissues would be rapidly remodeled by acute AR, and that the renin-angiotensin system would be involved in that acute remodeling. METHOD: The early LV adaptations to acute AR were evaluated serially over a period of 14 days, using a rat model. Adaptations were evaluated in vivo by echocardiography, and in vitro on explanted heart tissue after one, two, or 14 days. RESULTS: After 14 days, the left ventricle of AR rats was already significantly hypertrophied and dilated (end-diastolic diameter +16% (p
