Fiche du document
15 juin 2022
- 2206.07845
Sujets proches
Therapy Statistical data Cases, clinical reports, statistics Units Measurement, Units of State trials Statistical data Statistical analysis Statistical methods Statistical scienceCiter ce document
Yuehao Bai, « Optimality of Matched-Pair Designs in Randomized Controlled Trials », arXiv - économie
Partage / Export
Résumé
In randomized controlled trials (RCTs), treatment is often assigned by stratified randomization. I show that among all stratified randomization schemes which treat all units with probability one half, a certain matched-pair design achieves the maximum statistical precision for estimating the average treatment effect (ATE). In an important special case, the optimal design pairs units according to the baseline outcome. In a simulation study based on datasets from 10 RCTs, this design lowers the standard error for the estimator of the ATE by 10% on average, and by up to 34%, relative to the original designs.