Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.
Fiche du document
- doi: 10.1002/1873-3468.14335
- issn: 0014-5793
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1002/1873-3468.14335
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/35294049
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1873-3468
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_C1D722D17E1D4
info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/
Sujets proches
Fat tissue Body fat tissues Adipose tissue Fatty tissueCiter ce document
Y. Chen et al., « Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction. », Serveur académique Lausannois, ID : 10.1002/1873-3468.14335
Métriques
Partage / Export
Résumé
Adipose tissue regulates whole-body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin-dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue-specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and downregulation of fat-specific genes, which are aggravated on high-fat diet and during ageing. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis.