Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1002/acn3.396
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/28904989
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/2328-9503
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_DE765C4A014F5
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
M.H. van Coevorden-Hameete et al., « Antibodies to TRIM46 are associated with paraneoplastic neurological syndromes. », Serveur académique Lausannois, ID : 10.1002/acn3.396
Paraneoplastic neurological syndromes (PNS) are often characterized by the presence of antineuronal antibodies in patient serum or cerebrospinal fluid. The detection of antineuronal antibodies has proven to be a useful tool in PNS diagnosis and the search for an underlying tumor. Here, we describe three patients with autoantibodies to several epitopes of the axon initial segment protein tripartite motif 46 (TRIM46). We show that anti-TRIM46 antibodies are easy to detect in routine immunohistochemistry screening and can be confirmed by western blotting and cell-based assay. Anti-TRIM46 antibodies can occur in patients with diverse neurological syndromes and are associated with small-cell lung carcinoma.