Fiche du document
- doi: 10.1002/acn3.600
- issn: 2328-9503
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1002/acn3.600
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/30250859
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/2328-9503
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_85C6D66E54AC2
info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/
Sujets proches
Prediction Forecasts Futurology BiasCiter ce document
C. Pfeiffer et al., « Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma. », Serveur académique Lausannois, ID : 10.1002/acn3.600
Métriques
Partage / Export
Résumé
Prominent research in patients with disorders of consciousness investigated the electrophysiological correlates of auditory deviance detection as a marker of consciousness recovery. Here, we extend previous studies by investigating whether somatosensory deviance detection provides an added value for outcome prediction in postanoxic comatose patients. Electroencephalography responses to frequent and rare stimuli were obtained from 66 patients on the first and second day after coma onset. Multivariate decoding analysis revealed an above chance-level auditory discrimination in 25 patients on the first day and in 31 patients on the second day. Tactile discrimination was significant in 16 patients on the first day and in 23 patients on the second day. Single-day sensory discrimination was unrelated to patients' outcome in both modalities. However, improvement of auditory discrimination from first to the second day was predictive of good outcome with a positive predictive power (PPV) of 0.73 (CI = 0.52-0.88). Analyses considering the improvement of tactile, auditory and tactile, or either auditory or tactile discrimination showed no significant prediction of good outcome (PPVs = 0.58-0.68). Our results show that in the acute phase of coma deviance detection is largely preserved for both auditory and tactile modalities. However, we found no evidence for an added value of somatosensory to auditory deviance detection function for coma-outcome prediction.