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- doi: 10.1002/advs.202003761
- issn: 2198-3844
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info:eu-repo/semantics/altIdentifier/pmid/33977054
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_53CDCE390C812
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F. Fallegger et al., « MRI-Compatible and Conformal Electrocorticography Grids for Translational Research. », Serveur académique Lausannois, ID : 10.1002/advs.202003761
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Intraoperative electrocorticography (ECoG) captures neural information from the surface of the cerebral cortex during surgeries such as resections for intractable epilepsy and tumors. Current clinical ECoG grids come in evenly spaced, millimeter-sized electrodes embedded in silicone rubber. Their mechanical rigidity and fixed electrode spatial resolution are common shortcomings reported by the surgical teams. Here, advances in soft neurotechnology are leveraged to manufacture conformable subdural, thin-film ECoG grids, and evaluate their suitability for translational research. Soft grids with 0.2 to 10 mm electrode pitch and diameter are embedded in 150 µm silicone membranes. The soft grids are compatible with surgical handling and can be folded to safely interface hidden cerebral surface such as the Sylvian fold in human cadaveric models. It is found that the thin-film conductor grids do not generate diagnostic-impeding imaging artefacts (