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2014
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info:eu-repo/semantics/altIdentifier/doi/10.1007/978-1-62703-610-8_11
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info:eu-repo/semantics/altIdentifier/isbn/9781627036108
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_156FC9B26D1E7
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Huntington chronic progressive hereditary chorea Microcellular striatal syndrome Huntington's chorea Degenerative chorea Hereditary chorea Progressive hereditary chorea, Chronic Chronic progressive chorea HD (Disease) Huntington chorea Chronic progressive hereditary chorea Huntington disease HC (Disease) Lund-Huntington choreaCiter ce document
A. Delzor et al., « Lentiviral vectors in Huntington's disease research and therapy », Serveur académique Lausannois, ID : 10.1007/978-1-62703-610-8_11
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We describe here the potential of viral-mediated gene transfer for the modeling and treatment of Huntington's disease, focusing in particular on strategies for the tissue-specific targeting of various CNS cells. The protocols described here cover the design of lentiviral vectors, strategies for modifying their tropism, including the use of various envelopes and tissue-specific promoters, and the potential of miRNA to regulate transgene expression.