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2012
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Speciation (Biology) C-type RNA viruses Leukoviruses Retroviridae RNA tumor viruses Oncornaviruses Leukemogenic viruses Oncoviruses Infectious diseases Genes--Expression Cell degeneration Virus genomes Viral genomeCiter ce document
S. Desfarges et al., « Viral integration and consequences on host gene expression », Serveur académique Lausannois, ID : 10.1007/978-94-007-4899-6_7
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Upon cell infection, some viruses integrate their genome into the host chromosome, either as part of their life cycle (such as retroviruses), or incidentally. While possibly promoting long-term persistence of the virus into the cell, viral genome integration may also lead to drastic consequences for the host cell, including gene disruption, insertional mutagenesis and cell death, as well as contributing to species evolution. This review summarizes the current knowledge on viruses integrating their genome into the host genome and the consequences for the host cell.