Fiche du document
2011
- doi: 10.1007/s00018-011-0798-z
- issn: 1420-682X
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-011-0798-z
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/21863376
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1420-9071
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_7D095BF6B21B5
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Cell membrane receptors Receptors, Cell Cell surface receptorsCiter ce document
W. Held et al., « Cis-trans interactions of cell surface receptors: biological roles and structural basis. », Serveur académique Lausannois, ID : 10.1007/s00018-011-0798-z
Métriques
Partage / Export
Résumé
Cell surface receptors bind ligands expressed on other cells (in trans) in order to communicate with neighboring cells. However, an increasing number of cell surface receptors are found to also interact with ligands expressed on the same cell (in cis). These observations raise questions regarding the biological role of such cis interactions. Specifically, it is important to know whether cis and trans binding have distinct functional effects and, if so, how a single cell discriminates between interactions in cis versus trans. Further, what are the structural features that allow certain cell surface receptors to engage ligand both on the same as well as on an apposed cell membrane? Here, we summarize known examples of receptors that display cis-trans binding and discuss the emerging diversity of biological roles played by these unconventional two-way interactions, along with their structural basis.