CD73 expression in normal and pathological human hepatobiliopancreatic tissues.

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Serveur académique Lausannois

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info:eu-repo/semantics/altIdentifier/doi/10.1007/s00262-018-2290-1

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info:eu-repo/semantics/altIdentifier/pmid/30607549

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info:eu-repo/semantics/altIdentifier/eissn/1432-0851

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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_97044E6716715

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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5'-Nucleotidase/analysis; 5'-Nucleotidase/antagonists & inhibitors; Bile Duct Neoplasms/chemistry; Bile Duct Neoplasms/mortality; Bile Duct Neoplasms/pathology; Biliary Tract/chemistry; Carcinoma, Hepatocellular/chemistry; Carcinoma, Hepatocellular/mortality; Carcinoma, Hepatocellular/pathology; Carcinoma, Pancreatic Ductal/chemistry; Carcinoma, Pancreatic Ductal/mortality; Carcinoma, Pancreatic Ductal/pathology; Cholangiocarcinoma/chemistry; Cholangiocarcinoma/mortality; Cholangiocarcinoma/pathology; Epithelial-Mesenchymal Transition; GPI-Linked Proteins/analysis; GPI-Linked Proteins/antagonists & inhibitors; Humans; Immunohistochemistry; Liver/chemistry; Liver Neoplasms/chemistry; Liver Neoplasms/mortality; Liver Neoplasms/pathology; Pancreas/chemistry; Pancreatic Neoplasms/chemistry; Pancreatic Neoplasms/mortality; Pancreatic Neoplasms/pathology; Prognosis; CD73; Cholangiocarcinoma; Ecto-5′-nucleotidase; Hepatocellular carcinoma; Pancreatic carcinoma

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Carcinoma Cancers Malignancy (Cancer) Malignant tumors

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A. Sciarra et al., « CD73 expression in normal and pathological human hepatobiliopancreatic tissues. », Serveur académique Lausannois, ID : 10.1007/s00262-018-2290-1

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The tumor-expressed CD73 ectonucleotidase generates immune tolerance and promotes invasiveness via adenosine production from degradation of AMP. While anti-CD73 blockade treatment is a promising tool in cancer immunotherapy, a characterization of CD73 expression in human hepatobiliopancreatic system is lacking. CD73 expression was investigated by immunohistochemistry in a variety of non-neoplastic and neoplastic conditions of the liver, pancreas, and biliary tract. CD73 was expressed in normal hepatobiliopancreatic tissues with subcellular-specific patterns of staining: canalicular in hepatocytes, and apical in cholangiocytes and pancreatic ducts. CD73 was present in all hepatocellular carcinoma (HCC), in all pancreatic ductal adenocarcinoma (PDAC), and in the majority of intra and extrahepatic cholangiocellular carcinomas, whereas it was detected only in a subset of pancreatic neuroendocrine neoplasms and almost absent in acinar cell carcinoma. In addition to the canonical pattern of staining, an aberrant membranous and/or cytoplasmic expression was observed in invasive lesions, especially in HCC and PDAC. These two entities were also characterized by a higher extent and intensity of staining as compared to other hepatobiliopancreatic neoplasms. In PDAC, aberrant CD73 expression was inversely correlated with differentiation (p 

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