MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects.
Fiche du document
2013
- doi: 10.1007/s10072-012-1144-4
- issn: 1590-1874
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1007/s10072-012-1144-4
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/22752855
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1590-3478
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4187CB3E957E5
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Sclerosis, Multiple MS (Disease) illnessCiter ce document
S. Jilek et al., « MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects. », Serveur académique Lausannois, ID : 10.1007/s10072-012-1144-4
Métriques
Partage / Export
Résumé
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Myelin oligodendrocyte glycoprotein (MOG) and myelin oligodendrocyte basic protein (MOBP) were both shown to be highly encephalitogenic in animal models of MS. In contrast, the association of MOG- and MOBP-specific humoral or cellular immune responses and MS in humans is far less established. In this study, we sought to analyse MOG- and MOBP-specific T-cell responses in a large cohort of patients with various stages of the disease. Patients with other neurological diseases and healthy subjects were enrolled to serve as control study subjects. We determined the proliferation and the secretion of IFN-γ secretion in our cohort. We found that MOG-specific T-cell responses were higher and more frequent as compared to MOBP-specific ones. However, both MS patients and control study subjects had similar myelin-specific T-cell responses at the periphery, thus calling for more precise studies at CNS level.