Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements.
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4 mai 2018
- doi: 10.1007/s10856-018-6066-0
- issn: 0957-4530
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info:eu-repo/semantics/altIdentifier/doi/10.1007/s10856-018-6066-0
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info:eu-repo/semantics/altIdentifier/pmid/29728770
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info:eu-repo/semantics/altIdentifier/eissn/1573-4838
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_CA050E450D521
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J. Antons et al., « Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements. », Serveur académique Lausannois, ID : 10.1007/s10856-018-6066-0
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Résumé
Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is limited. In this study, we quantified a zone-dependent change of local elastic modulus of human femoral condyle cartilage by using an instrumented indentation technique. From the cartilage superficial zone towards the calcified layer, a gradient of elastic modulus values between 0.020 ± 0.003 MPa and 6.44 ± 1.02 MPa was measured. To validate the tissue quality, the histological tissue composition was visualized by glycosaminoglycan and collagen staining. This work aims to introduce a new protocol to investigate the zone-dependent mechanical properties of graded structures, such as human articular cartilage. From this knowledge, better cartilage repair strategies could be tailored in the future.