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2017
- doi: 10.1007/s40629-017-0037-8
- issn: 2197-0378
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info:eu-repo/semantics/altIdentifier/doi/10.1007/s40629-017-0037-8
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/29104849
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info:eu-repo/semantics/altIdentifier/pissn/2197-0378
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_F0F7AD1E7AD57
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
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Therapy Inflammatory process illnessCiter ce document
D. Simon et al., « Current concepts in eosinophilic esophagitis. », Serveur académique Lausannois, ID : 10.1007/s40629-017-0037-8
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Résumé
Eosinophilic esophagitis (EoE) is a disease entity first described in the 1990s, but showing an increasing incidence that is characterized clinically by esophageal dysfunction and histologically by a striking eosinophil infiltration. This article discusses new aspects of the pathogenesis, symptoms, diagnosis, and treatment of EoE. EoE affects both children and adults and is frequently associated with atopic disease and IgE sensitization. Barrier dysfunction and T‑helper 2 inflammation are considered to be pathogenetically important factors. Recently, a proton pump inhibitor (PPI)-sensitive EoE subtype as well as an EoE-like disorder have been described. Research in recent years has contributed to a better understanding of the disease spectrum and pathogenesis of EoE, including genetic dispositions, thereby laying the foundation for innovative treatment approaches.