Characterization of two receptors for TRAIL.

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Auteurs
Date

1997

Type de document
Périmètre
Langue
Identifiant
Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/S0014-5793(97)01231-3

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/9373179

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/0014-5793

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_25D695CC2FFE9

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Amino Acid Sequence; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Chromosome Mapping; Cloning, Molecular; Humans; Kinetics; Lymphocytes; Membrane Glycoproteins; Molecular Sequence Data; Muscle, Skeletal; Polymerase Chain Reaction; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sequence Tagged Sites; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha

Sujets proches En

Lymphotoxin TNF (Immunology) Cachectin Muscle Musculature Myodynamics Myology Nongranular leucocytes

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P. Schneider et al., « Characterization of two receptors for TRAIL. », Serveur académique Lausannois, ID : 10.1016/S0014-5793(97

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Two receptors for TRAIL, designated TRAIL-R2 and TRAIL-R3, have been identified. Both are members of the tumor necrosis factor receptor family. TRAIL-R2 is structurally similar to the death-domain-containing receptor TRAIL-R1 (DR-4), and is capable of inducing apoptosis. In contrast, TRAIL-R3 does not promote cell death. TRAIL-R3 is highly glycosylated and is membrane bound via a putative phosphatidylinositol anchor. The extended structure of TRAIL-R3 is due to the presence of multiple threonine-, alanine-, proline- and glutamine-rich repeats (TAPE repeats). TRAIL-R2 shows a broad tissue distribution, whereas the expression of TRAIL-R3 is restricted to peripheral blood lymphocytes (PBLs) and skeletal muscle. All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals.

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