TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.

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Date

1997

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Périmètre
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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/S1074-7613(00)80401-X

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/9430228

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/1074-7613

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_1D571B98E2980

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Adaptor Proteins, Signal Transducing; Apoptosis; Carrier Proteins/metabolism; Cell Line; Cytoplasm/metabolism; Fas-Associated Death Domain Protein; Humans; Jurkat Cells; NF-kappa B/metabolism; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor/metabolism; Signal Transduction; Tumor Cells, Cultured

Sujets proches En

Death--Philosophy Dying End of life

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P. Schneider et al., « TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. », Serveur académique Lausannois, ID : 10.1016/S1074-7613(00

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TRAIL induces apoptosis through two closely related receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that TRAIL may signal through heteroreceptor signaling complexes. Both TRAIL receptors bind the adaptor molecules FADD and TRADD, and both death signals are interrupted by a dominant negative form of FADD and by the FLICE-inhibitory protein FLIP. The recruitment of TRADD may explain the potent activation of NF-kappaB observed by TRAIL receptors. Thus, TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family.

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