Fiche du document
2015
- doi: 10.1016/j.ajpath.2015.04.002
- issn: 0002-9440
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ajpath.2015.04.002
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/26166807
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1525-2191
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_D4CF9AE4C2691
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Retinal Vitamin A aldehyde Retinaldehyde Retinene Inflammatory processCiter ce document
E. Bousquet et al., « Choroidal mast cells in retinal pathology: a potential target for intervention. », Serveur académique Lausannois, ID : 10.1016/j.ajpath.2015.04.002
Métriques
Partage / Export
Résumé
Mast cells are important in the initiation of ocular inflammation, but the consequences of mast cell degranulation on ocular pathology remain uncharacterized. We induced mast cell degranulation by local subconjunctival injection of compound 48/80. Initial degranulation of mast cells was observed in the choroid 15 minutes after the injection and increased up to 3 hours after injection. Clinical signs of anterior segment inflammation paralleled mast cell degranulation. With the use of optical coherence tomography, dilation of choroidal vessels and serous retinal detachments (SRDs) were observed and confirmed by histology. Subconjunctival injection of disodium cromoglycate significantly reduced the rate of SRDs, demonstrating the involvement of mast cell degranulation in posterior segment disorders. The infiltration of polymorphonuclear and macrophage cells was associated with increased ocular media concentrations of tumor necrosis factor-α, CXCL1, IL-6, IL-5, chemokine ligand 2, and IL-1β. Analysis of the amounts of vascular endothelial growth factor and IL-18 showed an opposite evolution of vascular endothelial growth factor compared with IL-18 concentrations, suggesting that they regulate each other's production. These findings suggest that the local degranulation of ocular mast cells provoked acute ocular inflammation, dilation, increased vascular permeability of choroidal vessels, and SRDs. The involvement of mast cells in retinal diseases should be further investigated. The pharmacologic inhibition of mast cell degranulation may be a potential target for intervention.