Fiche du document
13 mars 2023
- doi: 10.1016/j.ccell.2023.02.012
- issn: 1535-6108
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ccell.2023.02.012
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/36917953
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1878-3686
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_D95EAD5DCE0D5
info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/
Sujets proches
Carcinoma Cancers Malignancy (Cancer) Malignant tumorsCiter ce document
D. Hanahan et al., « Cancer hallmarks intersect with neuroscience in the tumor microenvironment. », Serveur académique Lausannois, ID : 10.1016/j.ccell.2023.02.012
Métriques
Partage / Export
Résumé
The mechanisms underlying the multistep process of tumorigenesis can be distilled into a logical framework involving the acquisition of functional capabilities, the so-called hallmarks of cancer, which are collectively envisaged to be necessary for malignancy. These capabilities, embodied both in transformed cancer cells as well as in the heterotypic accessory cells that together constitute the tumor microenvironment (TME), are conveyed by certain abnormal characteristics of the cancerous phenotype. This perspective discusses the link between the nervous system and the induction of hallmark capabilities, revealing neurons and neuronal projections (axons) as hallmark-inducing constituents of the TME. We also discuss the autocrine and paracrine neuronal regulatory circuits aberrantly activated in cancer cells that may constitute a distinctive "enabling" characteristic contributing to the manifestation of hallmark functions and consequent cancer pathogenesis.